(2E)-3-[[4-(1,1-DIMETHYLETHYL)PHENYL]SULFONYL]-2-PROPENENITRILE
BAY 11-7085
CAS: 196309-76-9
Molecular Formula: C13H15NO2S
(2E)-3-[[4-(1,1-DIMETHYLETHYL)PHENYL]SULFONYL]-2-PROPENENITRILE - Names and Identifiers
(2E)-3-[[4-(1,1-DIMETHYLETHYL)PHENYL]SULFONYL]-2-PROPENENITRILE - Physico-chemical Properties
| Molecular Formula | C13H15NO2S |
| Molar Mass | 249.33 |
| Density | 1.144 |
| Melting Point | 80-82℃ |
| Flash Point | 200℃ |
| Solubility | DMSO: >25mg/mL, soluble |
| Appearance | solid |
| Color | white |
| Storage Condition | Sealed in dry,Room Temperature |
| Sensitive | Light Sensitive |
| In vitro study | BAY11-7085 inhibited TNFα-induced expression of adhesion molecules E-selectin, VCAM-1, and ICAM-1 by inhibiting NF-κB, while there was no detectable cytotoxicity in HUVEC cells at 10 μm. BAY 11-7085 enhances the inhibition of NF kappaB activity by paclitaxel and reduces the viability of paclitaxel-treated cells. Furthermore, the binding of Bay11-7085 to LY294002 has a synergistic effect on apoptosis of PEL cells. |
| In vivo study | BAY11-7085 inhibition of meningitis-associated increased NF-κB activity resulted in an improvement in the clinical status of infected rats and a significant attenuation of meningitis-related CNS complications and meningitis. In athymic nude mice with Caov-3 cells, BAY 11-7085 was able to increase paclitaxel-induced inhibitory efficacy on intra-abdominal spread and ascites production. |
(2E)-3-[[4-(1,1-DIMETHYLETHYL)PHENYL]SULFONYL]-2-PROPENENITRILE - Risk and Safety
| WGK Germany | 3 |
| RTECS | UD1312500 |
| HS Code | 29309090 |
(2E)-3-[[4-(1,1-DIMETHYLETHYL)PHENYL]SULFONYL]-2-PROPENENITRILE - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.011 ml | 20.054 ml | 40.107 ml |
| 5 mM | 0.802 ml | 4.011 ml | 8.021 ml |
| 10 mM | 0.401 ml | 2.005 ml | 4.011 ml |
| 5 mM | 0.08 ml | 0.401 ml | 0.802 ml |
Last Update：2024-01-02 23:10:35
(2E)-3-[[4-(1,1-DIMETHYLETHYL)PHENYL]SULFONYL]-2-PROPENENITRILE - Introduction
BAY 11-7085 is a chemical with the chemical name (3E)-3-[(4-methylphenyl)sulfonyl]-2-propenitril. The following is an introduction to the nature, use, preparation and safety information of BAY 11-7085:
Nature:
BAY 11-7085 is a white or off-white crystalline solid with a chemical formula of C10H9NO2S and a relative molecular mass of 207.25. It has a melting point between 104-107°C and is less soluble in water.
Use:
BAY 11-7085 is widely used in biomedical research, especially in the field of cancer treatment. It is a typical nuclear factor-kappaB(NF-κB) inhibitor, which can inhibit cellular inflammatory and immune responses. In addition, BAY 11-7085 is also used as a reagent for the study of inflammatory diseases, neurodegenerative diseases and antiviral therapy.
Preparation Method:
The preparation method of BAY 11-7085 usually involves the process of chemical synthesis. The specific method can be carried out according to the description in the literature.
Safety Information:
BAY 11-7085 is a laboratory reagent and is limited to scientific use. In the use and storage, should be strictly in accordance with the chemical safety operation procedures, and follow the corresponding procedures and recommendations. Direct contact with BAY 11-7085 may cause irritation to skin, eyes, and mucous membranes, so contact should be avoided. Wear appropriate personal protective equipment, such as lab gloves and goggles, when using BAY 11-7085. In addition, do not expose BAY 11-7085 to open flames or high temperatures, and do not mix it with other chemicals such as oxidants. For safety reasons, it is recommended to read the relevant safety data and operating instructions before using BAY 11-7085. In case of any accident, seek medical attention immediately.
Nature:
BAY 11-7085 is a white or off-white crystalline solid with a chemical formula of C10H9NO2S and a relative molecular mass of 207.25. It has a melting point between 104-107°C and is less soluble in water.
Use:
BAY 11-7085 is widely used in biomedical research, especially in the field of cancer treatment. It is a typical nuclear factor-kappaB(NF-κB) inhibitor, which can inhibit cellular inflammatory and immune responses. In addition, BAY 11-7085 is also used as a reagent for the study of inflammatory diseases, neurodegenerative diseases and antiviral therapy.
Preparation Method:
The preparation method of BAY 11-7085 usually involves the process of chemical synthesis. The specific method can be carried out according to the description in the literature.
Safety Information:
BAY 11-7085 is a laboratory reagent and is limited to scientific use. In the use and storage, should be strictly in accordance with the chemical safety operation procedures, and follow the corresponding procedures and recommendations. Direct contact with BAY 11-7085 may cause irritation to skin, eyes, and mucous membranes, so contact should be avoided. Wear appropriate personal protective equipment, such as lab gloves and goggles, when using BAY 11-7085. In addition, do not expose BAY 11-7085 to open flames or high temperatures, and do not mix it with other chemicals such as oxidants. For safety reasons, it is recommended to read the relevant safety data and operating instructions before using BAY 11-7085. In case of any accident, seek medical attention immediately.
Last Update：2024-04-10 22:29:15
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Spot supply
Product Name: BAY 11-7085 Visit Supplier Webpage Request for quotationCAS: 196309-76-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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